Unraveling the effect of collagen damage on bone fracture using in situ synchrotron microtomography with deep learning

Abstract When studying bone fragility diseases, it is difficult to identify which factors reduce bone’s resistance fracture because these diseases alter at many length scales. Here, we investigate the contribution of nanoscale collagen behavior on macroscale toughness and microscale toughening mechanisms using a bovine heat-treatment model. This model assessed by developing an in situ testing technique for synchrotron radiation micro-computed tomography study evolution crack growth 3D. Low-dose imaging employed with deep learning denoise images while maintaining innate mechanical properties. We show that damage significantly reduces post-yield also find samples compromised network have reduced amounts deflection, main mechanism resistance. research demonstrates adversely affects overall bone.